Role of MAPK/ERK1/2 in the glucose deprivation-induced death in immunostimulated astroglia

@article{Yoo2005RoleOM,
  title={Role of MAPK/ERK1/2 in the glucose deprivation-induced death in immunostimulated astroglia},
  author={B. Yoo and Ji Woong Choi and B. Han and W. Kim and Hyoung-Chun Kim and K. Ko},
  journal={Neuroscience Letters},
  year={2005},
  volume={376},
  pages={171-176}
}
Recently we have reported that glucose deprivation induces the potentiated death and loss of ATP in immunostimulated astroglia via the production of NO and eventually peroxynitrite. This study examined the role of the ERK1/2 signaling pathways in the glucose deprivation-induced death of immunostimulated astroglia. Immunostimulation with LPS+IFN-gamma induced the sustained activation of ERK1/2 for up to 48 h. Glucose deprivation caused the loss of ATP and consequently cell death in… Expand
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