Role of MAP kinase signalling pathways in the mode of action of peroxisome proliferators.

@article{Cosulich2000RoleOM,
  title={Role of MAP kinase signalling pathways in the mode of action of peroxisome proliferators.},
  author={Sabina C. Cosulich and Nicolas James and Rebecca Roberts},
  journal={Carcinogenesis},
  year={2000},
  volume={21 4},
  pages={
          579-84
        }
}
Peroxisome proliferators (PPs) are a class of non-genotoxic chemicals that cause rodent liver enlargement and hepatocarcinogenesis. In primary rat hepatocytes, PPs cause cell proliferation, suppression of apoptosis and peroxisome proliferation. We have investigated the role of different families of mitogen-activated protein (MAP) kinases in the mode of action of PPs. Addition of 50 microM nafenopin to primary rat hepatocyte cultures caused weak activation of extracellular signal regulated… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 10 CITATIONS

References

Publications referenced by this paper.
SHOWING 1-10 OF 22 REFERENCES

MAP kinase homologue which is stimulated by cellular stresses and interleukin - 1

  • K. Uchida, M. Shiraishi, Y. Naito, Y. Torii, Y. Nakamura, T. Osawa
  • FEBS Lett .
  • 1999

Mitogen - activated protein kinases : specific messages from ubiquitous messengers

  • S. Chevalier, N. Macdonald, R. A. Roberts, M. J. Schaeffer
  • Mol . Cell . Biol .
  • 1999

SB 202190 , a selective inhibitor of p 38 mitogen - activated protein kinase , is a powerfulcells are causally responsible for the mitogenic effect of peroxisome proliferators

  • C. L. Manthey, S. W. Wang, S. D. Kinney, Z. Yao
  • Carcinogenesis
  • 1998

p 38 and extracellular signal - regulated MAP kinase

  • H. Camp, S. Tafuri, +6 authors G. Haegeman
  • J . Biol . Chem .
  • 1998

Similar Papers

Loading similar papers…