Role of Lutein Supplementation in the Management of Age-Related Macular Degeneration: Meta-Analysis of Randomized Controlled Trials

@article{Wang2014RoleOL,
  title={Role of Lutein Supplementation in the Management of Age-Related Macular Degeneration: Meta-Analysis of Randomized Controlled Trials},
  author={Xin Wang and Cai-hui Jiang and Ying Zhang and Yan Gong and Xiaofei Chen and Mao-nian Zhang},
  journal={Ophthalmic Research},
  year={2014},
  volume={52},
  pages={198 - 205}
}
Objective: The conduct of this meta-analysis aimed at examining the individual role of lutein as a dietary supplement in improving conditions of age-related macular degeneration (AMD) from the data generated from randomized controlled trials (RCTs). Method: The literature search was made in multiple electronic databases. Eligibility criteria were RCTs that recruited AMD patients or individuals at risk and evaluated lutein supplementation efficacy against placebo. The quality of the trials was… Expand
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TLDR
It is demonstrated that lutein supplementation increases macular pigment optical density, as assessed with an objective study, and indicates that patients who show a pronounced increase in MPOD also benefit in terms of visual function. Expand
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Looking forward, further studies are needed with more patients, of both genders, and for longer periods of time to assess long-term effects of lutein or lUTEin together with a broad spectrum of antioxidants, vitamins, and minerals in the treatment of atrophic age-related macular degeneration. Expand
Lutein supplementation over a one-year period in early AMD might have a mild beneficial effect on visual acuity: the CLEAR study.
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L supplementation increases MPOD levels in early stage AMD patients, and according to the VA measurements, the progress of the disease might be slowed in some patients with augmented levels of MP. Expand
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Dietary lutein and zeaxanthin is not significantly associated with a reduced risk of early AMD, whereas an increase in the intake of these carotenoids may be protective against late AMD, however, additional studies are needed to confirm these relationships. Expand
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