Role of Lithium Augmentation in the Management of Major Depressive Disorder

@article{Bauer2014RoleOL,
  title={Role of Lithium Augmentation in the Management of Major Depressive Disorder},
  author={Michael Bauer and Mazda Adli and Roland Ricken and Emanuel Severus and Maximilian Pilhatsch},
  journal={CNS Drugs},
  year={2014},
  volume={28},
  pages={331-342}
}
The high rate of non-responders to initial treatment with antidepressants requires subsequent treatment strategies such as augmentation of antidepressants. Clinical guidelines recommend lithium augmentation as a first-line treatment strategy for non-responding depressed patients. The objectives of this review were to discuss the current place of lithium augmentation in the management of treatment-resistant depression and to review novel findings concerning lithium’s mechanisms of action. We… 
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