Role of Lithium Augmentation in the Management of Major Depressive Disorder
@article{Bauer2014RoleOL, title={Role of Lithium Augmentation in the Management of Major Depressive Disorder}, author={Michael Bauer and Mazda Adli and Roland Ricken and Emanuel Severus and Maximilian Pilhatsch}, journal={CNS Drugs}, year={2014}, volume={28}, pages={331-342} }
The high rate of non-responders to initial treatment with antidepressants requires subsequent treatment strategies such as augmentation of antidepressants. Clinical guidelines recommend lithium augmentation as a first-line treatment strategy for non-responding depressed patients. The objectives of this review were to discuss the current place of lithium augmentation in the management of treatment-resistant depression and to review novel findings concerning lithium’s mechanisms of action. We…
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References
SHOWING 1-10 OF 102 REFERENCES
Lithium’s Emerging Role in the Treatment of Refractory Major Depressive Episodes: Augmentation of Antidepressants
- Psychology, MedicineNeuropsychobiology
- 2010
Augmentation of antidepressants with lithium is currently the best-evidenced augmentation therapy in the treatment of depressed patients who do not respond to antidepressants.
Lithium augmentation in treatment-resistant depression: clinical evidence, serotonergic and endocrine mechanisms.
- Psychology, MedicinePharmacopsychiatry
- 2003
New data on the efficacy and mechanism of action of lithium augmentation are reviewed, showing an unexpected and marked increase in the ACTH and cortisol response in the combined DEX/CRH test.
Augmentation strategies for treatment-resistant depression
- Psychology, MedicineCurrent opinion in psychiatry
- 2009
Lithium and triiodothyronin (T3) augmentation of tricyclic agents remains the best studied strategy.
Acceleration and augmentation of antidepressants with lithium for depressive disorders: two meta-analyses of randomized, placebo-controlled trials.
- Psychology, MedicineThe Journal of clinical psychiatry
- 2007
There is firmevidence for lithium as an effective augmentation strategy but only modest evidence for lithium to accelerate response to antidepressants in patients with depressive disorders.
Predictors of efficacy in lithium augmentation for treatment-resistant depression.
- Psychology, MedicineJournal of affective disorders
- 2010
Lithium augmentation compared with phenelzine in treatment-resistant depression in the elderly: an open, randomized, controlled trial.
- Psychology, MedicineThe Journal of clinical psychiatry
- 2007
Lithium was more effective than phenelzine in elderly patients with treatment-resistant major depressive disorder, while tolerance of both treatments was remarkably good in this group of elderly inpatients with many comorbid medical disorders.
Adjunct low dose lithium carbonate in treatment-resistant depression: a placebo-controlled study.
- Medicine, PsychologyJournal of clinical psychopharmacology
- 1988
Patients in this study were treated with a lower dose of lithium, the duration of conventional antidepressant therapy was longer, and they were less depressed and possibly depressed for a longer period, which suggests that lithium is indeed an effective adjunct in some patients with treatment-resistant depression.
Lithium Augmentation of Nortriptyline for Subjects Resistant to Multiple Antidepressants
- Psychology, MedicineJournal of clinical psychopharmacology
- 2003
The data suggest limited usefulness of lithium augmentation for patients refractory to multiple treatments, and more definitive data await the outcome of the NIMH Sequential Treatment Alternatives to Relieve Depression (STAR*D) study.
Predictors of response to lithium augmentation in tricyclic antidepressant-resistant depression.
- Psychology, MedicineJournal of affective disorders
- 2001
Double-blind, placebo-controlled trial of the use of lithium to augment antidepressant medication in continuation treatment of unipolar major depression.
- Psychology, MedicineThe American journal of psychiatry
- 2000
Lithium augmentation in the continuation phase of treatment of unipolar major depressive disorder effectively protects patients against a relapse.