Role of Lipid in Sulfite-dependent Propofol Dimerization

@article{Baker2004RoleOL,
  title={Role of Lipid in Sulfite-dependent Propofol Dimerization},
  author={Max T. Baker and Marc S. Gregerson and Mohamed Naguib},
  journal={Anesthesiology},
  year={2004},
  volume={100},
  pages={1235-1241}
}
Background: During long-term intravenous infusions, sulfite in sulfite-containing propofol emulsions can cause the peroxidation of lipid and dimerization of propofol. This study evaluated the role of lipid in sulfite-dependent propofol dimerization by determining the effects of individual fatty acids in soybean oil emulsion and peroxidized lipids in a model system. Methods: Individual fatty acids, stearic (18:0), oleic (18:1), linoleic (18:2), linolenic (18:3), and arachidonic (20:4), were… 
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