Role of Lipid Peroxidation-Derived α, β-Unsaturated Aldehydes in Vascular Dysfunction

@inproceedings{Lee2013RoleOL,
  title={Role of Lipid Peroxidation-Derived α, β-Unsaturated Aldehydes in Vascular Dysfunction},
  author={Seung Eun Lee and Yong Seok Park},
  booktitle={Oxidative medicine and cellular longevity},
  year={2013}
}
Vascular diseases are the most prominent cause of death, and inflammation and vascular dysfunction are key initiators of the pathophysiology of vascular disease. Lipid peroxidation products, such as acrolein and other α, β-unsaturated aldehydes, have been implicated as mediators of inflammation and vascular dysfunction. α, β-Unsaturated aldehydes are toxic because of their high reactivity with nucleophiles and their ability to form protein and DNA adducts without prior metabolic activation… CONTINUE READING

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References

Publications referenced by this paper.
SHOWING 1-10 OF 73 REFERENCES

The molecular effects of acrolein.

  • Toxicological sciences : an official journal of the Society of Toxicology
  • 2000
VIEW 5 EXCERPTS
HIGHLY INFLUENTIAL

Role of endoplasmic reticulum stress in acrolein-induced endothelial activation

P.Haberzettl, E. Vladykovskaya, S. Srivastava, andA. Bhatnagar
  • Toxicology and Applied Pharmacology, vol. 234, no. 1, pp. 14–24, 2009.
  • 2009
VIEW 3 EXCERPTS
HIGHLY INFLUENTIAL