Role of Leukotriene in Inflammation and Antileukotriene Therapy

  title={Role of Leukotriene in Inflammation and Antileukotriene Therapy},
  author={Biren N. Shah and Nitin P. Patel and Priyanka R. Pandya},
The leukotrienes arise from oxidative metabolism of arachidonic acid through the action of the 5-lipoxygenase enzyme, leading to the unstable allylic epoxide leukotriene A4. This intermediate represents the substrate for two different specific enzymes, namely leukotriene A4-hydrolase and leukotriene C4-synthase, generating LTB4 and cysteinyl leukotrienes, respectively. LTC4 and LTD4 are potent contracting agents of smooth muscle in airways and blood vessels. LTB4 is known as a potent… CONTINUE READING


Publications referenced by this paper.

Luster BLT 1 and BLT 2 : the leukotriene B 4 receptors Prostaglandins

  • Andrew M. Tager, D Andrew
  • Leukotrienes and Essential Fatty Acids
  • 2006

Chowd The dynamics of acute inflammation

  • Rukmini Kumara, Gilles Clermontb, Yoram Vodovotzc, C Carson
  • Journal of Theoretical Biology ,
  • 2004

Evans The cysteinyl leukotriene receptors Prostaglandins , Leukotrienes and Essential Fatty Acids

  • F Jilly
  • 2003

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