Role of Leukotriene in Inflammation and Antileukotriene Therapy

@inproceedings{Shah2008RoleOL,
  title={Role of Leukotriene in Inflammation and Antileukotriene Therapy},
  author={Biren N. Shah and Nitin P. Patel and Priyanka R. Pandya},
  year={2008}
}
The leukotrienes arise from oxidative metabolism of arachidonic acid through the action of the 5-lipoxygenase enzyme, leading to the unstable allylic epoxide leukotriene A4. This intermediate represents the substrate for two different specific enzymes, namely leukotriene A4-hydrolase and leukotriene C4-synthase, generating LTB4 and cysteinyl leukotrienes, respectively. LTC4 and LTD4 are potent contracting agents of smooth muscle in airways and blood vessels. LTB4 is known as a potent… CONTINUE READING

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