Role of Lactobacillus in the Prevention of Antibiotic‐Associated Diarrhea: A Meta‐analysis

  title={Role of Lactobacillus in the Prevention of Antibiotic‐Associated Diarrhea: A Meta‐analysis},
  author={Pramodini B. Kale-Pradhan and Harjot K. Jassaly and Sheila M. Wilhelm},
  journal={Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy},
STUDY OBJECTIVE To evaluate the efficacy of a Lactobacillus probiotic single-agent regimen in preventing antibiotic-associated diarrhea (AAD. [] Key Method Patients. A total of 1862 pediatric and adult patients who received a Lactobacillus single-agent regimen or placebo for the prevention of AAD.

Randomised clinical trial: the synbiotic food supplement Probiotical vs. placebo for acute gastroenteritis in children

Aliment Pharmacol Ther 2011; 34: 862–867

A mixture of Lactobacillus species isolated from traditional fermented foods promote recovery from antibiotic‐induced intestinal disruption in mice

This study evaluated the antibiotic‐induced changes in microbial ecology, intestinal dysbiosis and low‐grade inflammation; and the combined effect of four different Lactobacillus species on recovery

Efficacy of probiotics in the prevention of antibiotic-associated diarrhoea (AAD) in children - a review

There is a clear evidence for the beneficial effects of specific probiotics and yogurt in AAD in children and there is a detailed evaluation of study design, methodology, data analysis and interpretation.

Role of Lactobacillus in the prevention of Clostridium difficile‐associated diarrhea: a meta‐analysis of randomized controlled trials

There is a sufficient evidence to recommend Lactobacillus (L. acidophilus and L. casei) as a prevention therapy for CDAD, according to a meta‐analysis of seven placebo‐controlled RCTs that evaluated the prevention of CDAD.

Probiotics for the prevention of pediatric antibiotic-associated diarrhea.

Results from 33 trials reporting on the incidence of diarrhea show a precise benefit from probiotics compared to active, placebo or no treatment control, and heterogeneity indicated that high dose is more effective than low probiotic dose.


A summary of the scientific evidence supporting the principal biological effects of the probiotics in digestive function, immune response, andlipid profile, relevant in the functional food development is presented.

Efficacy of the Probiotic Probiotical Confirmed in Acute Gastroenteritis

The test product was shown to normalize stool consistency significantly more rapidly than the placebo, and these data confirm the findings from a previous study in a larger group of children performed in a primary healthcare setting.

Effect of Probiotic Lactobacillus (Lacidofil® Cap) for the Prevention of Antibiotic-associated Diarrhea: A Prospective, Randomized, Double-blind, Multicenter Study

Although the Lacidofil® cap does not reduce the rate of occurrence of AAD in adult patients with respiratory tract infection who have taken antibiotics, the Lactobacillus group maintains their bowel habits to a greater extent than the placebo group.

Probiotics for the prevention of pediatric antibiotic-associated diarrhea.

The results from 22/23 trials reporting on the incidence of diarrhea show a precise benefit from probiotics compared to active, placebo or no treatment control, and this benefit remained statistically significant in an extreme plausible situation.



Meta‐analysis: the effect of probiotic administration on antibiotic‐associated diarrhoea

This data indicates that using probiotic preparations based on isolating Lactobacillus spp.

Clinical trial: effectiveness of Lactobacillus rhamnosus (strains E/N, Oxy and Pen) in the prevention of antibiotic‐associated diarrhoea in children

Evidence that probiotic administration can lower the risk of antibiotic‐associated diarrhoea is limited to certain micro‐organisms.

In vitro growth control of selected pathogens by Lactobacillus acidophilus‐ and Lactobacillus casei‐fermented milk

Aims:  Food‐borne pathogen inhibition was tested in the presence of a mixture of Lactobacillus acidophilus and Lactobacillus casei during fermentation under controlled pH conditions.

Prevention of antibiotic-associated diarrhea in infants by probiotics.

Results of the study showed that the group receiving probiotics had fewer diarrheal episodes than the control group, although the numbers were too small for statistical analysis.

Meta-Analysis of Probiotics for the Prevention of Antibiotic Associated Diarrhea and the Treatment of Clostridium difficile Disease

  • L. Mcfarland
  • Medicine, Biology
    The American Journal of Gastroenterology
  • 2006
Three types of probiotics (Saccharomyces boulardii, Lactobacillus rhamnosus GG, and probiotic mixtures) significantly reduced the development of antibiotic-associated diarrhea.

Probiotics for pediatric antibiotic-associated diarrhea: a meta-analysis of randomized placebo-controlled trials

The potential protective effects of probiotics to prevent antibiotic-associated diarrhea in children do not withstand intention-to-treat analysis, and further studies (with limited losses of subjects to follow-up) are merited.

A Double-Blind, Placebo-Controlled Study of the Efficacy of Lactinex in the Prophylaxis of Amoxicillin-Induced Diarrhea

The Lactobacillus preparation did not appear to consistently prevent diarrhea in this patient population, and patients' age, diet, and parental definition of diarrhea were factors that may have influenced the results.

Prophylactic Lactobacillus GGReduces Antibiotic-Associated Diarrhea in Children With Respiratory Infections: A Randomized Study

The incidence of diarrhea after antimicrobial treatment in children with no history of antimicrobial use during the previous 3 months was evaluated and the preventive potential of Lactobacillus rhamnosus GG, a probiotic strain with a documented safety record, was assessed.

Lack of effect of Lactobacillus GG on antibiotic-associated diarrhea: a randomized, placebo-controlled trial.

Lactobacillus GG in a dose of 20 x 10(9) CFU/d did not reduce the rate of occurrence of diarrhea in this sample of 267 adult patients taking antibiotics initially administered in the hospital setting.