Role of LXRs in control of lipogenesis.

  title={Role of LXRs in control of lipogenesis.},
  author={Joseph R Schultz and Hong Hai Tu and Arnold Luk and Joyce J. Repa and Julio Alfonso Cruz Medina and Li Li and Susan W. Schwendner and Shaohui Wang and Martin J. M. C. Thoolen and David J Mangelsdorf and Kevin D. Lustig and Bei Shan},
  journal={Genes & development},
  volume={14 22},
The discovery of oxysterols as the endogenous liver X receptor (LXR) ligands and subsequent gene targeting studies in mice provided strong evidence that LXR plays a central role in cholesterol metabolism. The identification here of a synthetic, nonsteroidal LXR-selective agonist series represented by T0314407 and T0901317 revealed a novel physiological role of LXR. Oral administration of T0901317 to mice and hamsters showed that LXR activated the coordinate expression of major fatty acid… CONTINUE READING
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