Role of LIM kinases in normal and psoriatic human epidermis.

  title={Role of LIM kinases in normal and psoriatic human epidermis.},
  author={Masaru Honma and Salvador Aznar Benitah and Fiona M Watt},
  journal={Molecular biology of the cell},
  volume={17 4},
We present evidence that LIM kinases can control cell adhesion and compaction in human epidermis. LIMK2 is expressed in the epidermal basal layer and signals downstream of the GTPase Rac1 to promote extracellular matrix adhesion and inhibit terminal differentiation. Conversely, LIMK1 is expressed in the upper granular layers and phosphorylates and inhibits cofilin. Expression of LIMK1 is lost in psoriatic lesions and other skin disorders characterized by lack of cell compaction in the… CONTINUE READING