Role of LAG-3 in regulatory T cells.

  title={Role of LAG-3 in regulatory T cells.},
  author={C C Huang and Creg J Workman and Dallas B. Flies and Xiaoyu Pan and Aimee L. Marson and Gang Zhou and Edward L. Hipkiss and Sowmya Ravi and Jeanne Kowalski and Hyam I. Levitsky and Jonathan D. Powell and Drew Mark Pardoll and Charles G. Drake and Dario A. A. Vignali},
  volume={21 4},
Regulatory T cells (Tregs) limit autoimmunity but also attenuate the magnitude of antipathogen and antitumor immunity. Understanding the mechanism of Treg function and therapeutic manipulation of Tregs in vivo requires identification of Treg-selective receptors. A comparative analysis of gene expression arrays from antigen-specific CD4(+) T cells differentiating to either an effector/memory or a regulatory phenotype revealed Treg-selective expression of LAG-3, a CD4-related molecule that binds… CONTINUE READING
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