Role of L-type Ca2+ channels in neural stem/progenitor cell differentiation.

  title={Role of L-type Ca2+ channels in neural stem/progenitor cell differentiation.},
  author={Marcello D'Ascenzo and Roberto Piacentini and Patrizia Casalbore and Manuela Budoni and Roberto Pallini and Gian Battista Azzena and Claudio Grassi},
  journal={The European journal of neuroscience},
  volume={23 4},
Ca(2+) influx through voltage-gated Ca(2+) channels, especially the L-type (Ca(v)1), activates downstream signaling to the nucleus that affects gene expression and, consequently, cell fate. We hypothesized that these Ca(2+) signals may also influence the neuronal differentiation of neural stem/progenitor cells (NSCs) derived from the brain cortex of postnatal mice. We first studied Ca(2+) transients induced by membrane depolarization in Fluo 4-AM-loaded NSCs using confocal microscopy… CONTINUE READING

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