Role of Kupffer cells and gut-derived endotoxins in alcoholic liver injury.

@article{Enomoto2000RoleOK,
  title={Role of Kupffer cells and gut-derived endotoxins in alcoholic liver injury.},
  author={Nobuyuki Enomoto and Kenichi Ikejima and Blair U. Bradford and Chantal A. Rivera and Hiroshi Kono and Masahisa Goto and Shunhei Yamashina and Peter Schemmer and Tsuneo Kitamura and Hirosumi Oide and Yoshiyuki Takei and Miyoko Hirose and Hiroyuki Shimizu and Akihisa Miyazaki and David Allen Brenner and N. Hamada Sato and Ronald Glenn. Thurman},
  journal={Journal of gastroenterology and hepatology},
  year={2000},
  volume={15 Suppl},
  pages={
          D20-5
        }
}
The hepatotoxic effects of alcohol have been described in detail, but factors responsible for its hepatotoxicity have only partially been characterized. For example, it is known that chronic ethanol ingestion increases hepatotoxicity and produces fatty liver, hepatitis and cirrhosis. However, acute ethanol consumption reduces endotoxin hepatotoxicity. It now appears that Kupffer cells participate in several aspects of these phenomena. Previously, most studies on the effects of alcohol on liver… CONTINUE READING
BETA

Similar Papers

Citations

Publications citing this paper.
SHOWING 1-10 OF 43 CITATIONS

Taurine alleviates lipopolysaccharide-induced liver injury by anti-inflammation and antioxidants in rats

  • Molecular medicine reports
  • 2017
VIEW 7 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Innate immunity in alcoholic liver disease.

  • American journal of physiology. Gastrointestinal and liver physiology
  • 2011
VIEW 5 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Pathogenesis of the hyperlipidemia of Gram-negative bacterial sepsis may involve pathomorphological changes in liver sinusoidal endothelial cells.

  • International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases
  • 2010
VIEW 3 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED