Role of Kinins in Inflammatory Responses

  title={Role of Kinins in Inflammatory Responses},
  author={Timothy C. Rodell and Yugen Naidoo and Professor Kanti D. Bhoola},
  journal={Clinical Immunotherapeutics},
Kinins are ubiquitous mediators that produce many of the cardinal manifestations of inflammation, and for that reason are an important target for therapeutic intervention. The cellular effects produced by the vasoactive kinin peptides are mediated by at least 2 different classes of receptors, B1 and B2. The development of specific, competitive antagonists of these receptors has provided a powerful tool for elucidating the physiopathological actions of kinins. Considerable evidence from in vitro… CONTINUE READING