Role of K(+) channel expression in polyamine-dependent intestinal epithelial cell migration.

@article{Wang2000RoleOK,
  title={Role of K(+) channel expression in polyamine-dependent intestinal epithelial cell migration.},
  author={J Y Wang and J Wang and Vera A. Golovina and L Li and Oleksandr Platoshyn and J X Yuan},
  journal={American journal of physiology. Cell physiology},
  year={2000},
  volume={278 2},
  pages={C303-14}
}
  • J Y Wang, J Wang, +3 authors J X Yuan
  • Published 2000 in American journal of physiology. Cell physiology
Polyamines are essential for cell migration during early mucosal restitution after wounding in the gastrointestinal tract. Activity of voltage-gated K(+) channels (Kv) controls membrane potential (E(m)) that regulates cytoplasmic free Ca(2+) concentration ([Ca(2+)](cyt)) by governing the driving force for Ca(2+) influx. This study determined whether polyamines are required for the stimulation of cell migration by altering K(+) channel gene expression, E(m), and [Ca(2+)](cyt) in intestinal… CONTINUE READING
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