Role of K+ channels in regulating spontaneous activity in detrusor smooth muscle in situ in the mouse bladder.

@article{Hayase2009RoleOK,
  title={Role of K+ channels in regulating spontaneous activity in detrusor smooth muscle in situ in the mouse bladder.},
  author={Masa Hayase and Hikaru Hashitani and Kenjiro Kohri and Hikaru Suzuki},
  journal={The Journal of urology},
  year={2009},
  volume={181 5},
  pages={2355-65}
}
PURPOSE We investigated the functional role of K(+) channels for regulating spontaneous activity in mouse bladder detrusor smooth muscle. MATERIALS AND METHODS The effects of different K(+) channels blockers on spontaneous changes in membrane potential and intracellular Ca(2+) dynamics were examined using intracellular recording techniques and Ca(2+) imaging with fluo-4 fluorescence, respectively. RESULTS Detrusor smooth muscle generated spontaneous action potentials and Ca(2+) transients… CONTINUE READING

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