Role of K+‐channels in homotaurine‐induced analgesia

@article{Serrano2001RoleOK,
  title={Role of K+‐channels in homotaurine‐induced analgesia},
  author={M. Serrano and J. Serrano and I. Asadi and A. Fern{\'a}ndez and M. C. Serrano-Martino},
  journal={Fundamental \& Clinical Pharmacology},
  year={2001},
  volume={15}
}
In previous articles, antinociceptive activity for homotaurine has been demonstrated to be mediated by opioid, GABAergic and cholinergic mechanisms. GABAB‐agonists affect K+‐channels and it is known that K+‐channels modulate specific activation of opioid receptors. In this study, we examined the involvement of K+‐channels in the antinociceptive activity of homotaurine (22–445 mg/kg). Antinociceptive response was obtained after icv pretreatment with the channel specific blockers 4‐aminopyridine… Expand
Potassium channels and pain: present realities and future opportunities.

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