Role of Jhdm2a in regulating metabolic gene expression and obesity resistance

@article{Tateishi2009RoleOJ,
  title={Role of Jhdm2a in regulating metabolic gene expression and obesity resistance},
  author={Keisuke Tateishi and Yasunori Okada and Eric M. Kallin and Yi Zhang},
  journal={Nature},
  year={2009},
  volume={458},
  pages={757-761}
}
Recent studies indicate that the methylation state of histones can be dynamically regulated by histone methyltransferases and demethylases. The H3K9-specific demethylase Jhdm2a (also known as Jmjd1a and Kdm3a) has an important role in nuclear hormone receptor-mediated gene activation and male germ cell development. Through disruption of the Jhdm2a gene in mice, here we demonstrate that Jhdm2a is critically important in regulating the expression of metabolic genes. The loss of Jhdm2a function… CONTINUE READING
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