Role of JNK in a Trp53-Dependent Mouse Model of Breast Cancer

  title={Role of JNK in a Trp53-Dependent Mouse Model of Breast Cancer},
  author={Cristina Cellurale and Claire R. Weston and Judith Reilly and David S. Garlick and D Joseph Jerry and Hayla K. Sluss and Roger J Davis},
  booktitle={PloS one},
The cJun NH2-terminal kinase (JNK) signal transduction pathway has been implicated in mammary carcinogenesis. To test the role of JNK, we examined the effect of ablation of the Jnk1 and Jnk2 genes in a Trp53-dependent model of breast cancer using BALB/c mice. We detected no defects in mammary gland development in virgin mice or during lactation and involution in control studies of Jnk1(-/-) and Jnk2(-/-) mice. In a Trp53(-/+) genetic background, mammary carcinomas were detected in 43% of… CONTINUE READING

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