Role of JAK2 V617F mutation and aberrant expression of microRNA-143 in myeloproliferative neoplasms.

Abstract

BACKGROUND Myeloproliferative neoplasms (MPNs) are clonal myeloid disorders characterized by the overproduction of mature blood cells. The pathogenetic hallmark of MPNs is the dysregulation of JAK-STAT signaling, usually associated with the JAK2 V617F mutation. Multiple additional genetic and epigenetic alterations that constitutively activate the JAK-STAT… (More)
DOI: 10.1515/cclm-2014-0858

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