Role of JAK2 V617F mutation and aberrant expression of microRNA-143 in myeloproliferative neoplasms.


BACKGROUND Myeloproliferative neoplasms (MPNs) are clonal myeloid disorders characterized by the overproduction of mature blood cells. The pathogenetic hallmark of MPNs is the dysregulation of JAK-STAT signaling, usually associated with the JAK2 V617F mutation. Multiple additional genetic and epigenetic alterations that constitutively activate the JAK-STAT… (More)
DOI: 10.1515/cclm-2014-0858


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