Role of J chain in secretory immunoglobulin formation.

  title={Role of J chain in secretory immunoglobulin formation.},
  author={Finn-Eirik Johansen and Ranveig Braathen and P E R Brandtzaeg},
  journal={Scandinavian journal of immunology},
  volume={52 3},
The joining (J) chain is a small polypeptide, expressed by mucosal and glandular plasma cells, which regulates polymer formation of immunoglobulin (Ig)A and IgM. J-chain incorporation into polymeric IgA (pIgA, mainly dimers) and pentameric IgM endows these antibodies with several salient features. First, a high valency of antigen-binding sites, which makes… CONTINUE READING