Role of J Chain in Secretory Immunoglobulin Formation

@article{Johansen2000RoleOJ,
  title={Role of J Chain in Secretory Immunoglobulin Formation},
  author={Johansen and Braathen and Brandtzaeg},
  journal={Scandinavian Journal of Immunology},
  year={2000},
  volume={52}
}
The joining (J) chain is a small polypeptide, expressed by mucosal and glandular plasma cells, which regulates polymer formation of immunoglobulin (Ig)A and IgM. J‐chain incorporation into polymeric IgA (pIgA, mainly dimers) and pentameric IgM endows these antibodies with several salient features. First, a high valency of antigen‐binding sites, which makes them suitable for agglutinating bacteria and viruses; little or no complement‐activating potential, which allows them to operate in a… Expand
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