Role of Intestinal Microbiota in Transformation of Bismuth and Other Metals and Metalloids into Volatile Methyl and Hydride Derivatives in Humans and Mice

@article{Michalke2008RoleOI,
  title={Role of Intestinal Microbiota in Transformation of Bismuth and Other Metals and Metalloids into Volatile Methyl and Hydride Derivatives in Humans and Mice},
  author={K. Michalke and A. Schmidt and Britta Huber and J{\"o}rg Meyer and M. Sulkowski and A. Hirner and J. Boertz and F. Mosel and P. Dammann and G. Hilken and H. Hedrich and M. Dorsch and A. Rettenmeier and R. Hensel},
  journal={Applied and Environmental Microbiology},
  year={2008},
  volume={74},
  pages={3069 - 3075}
}
ABSTRACT The present study shows that feces samples of 14 human volunteers and isolated gut segments of mice (small intestine, cecum, and large intestine) are able to transform metals and metalloids into volatile derivatives ex situ during anaerobic incubation at 37°C and neutral pH. Human feces and the gut of mice exhibit highly productive mechanisms for the formation of the toxic volatile derivative trimethylbismuth [(CH3)3Bi] at rather low concentrations of bismuth (0.2 to 1 μmol kg−1 [dry… Expand
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