Role of Interferon-gamma in GVHD and GVL.

  title={Role of Interferon-gamma in GVHD and GVL.},
  author={Yong-guang Yang and Hui Wang and Wannee Asavaroengchai and Bimalangshu R. Dey},
  journal={Cellular & molecular immunology},
  volume={2 5},
Interferon (IFN)-gamma, a potent proinflammatory cytokine produced by multiple types of cells (e.g., activated T, NK and NKT cells), plays important and complex roles in both innate and adaptive immune responses. There may be a correlation between the IFNgamma level and GVHD severity in patients receiving allogeneic hematopoietic cell transplantation. However, such a correlation may just reflect the presence of large numbers of activated T cells, and does not necessarily imply a harmful role of… CONTINUE READING
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