Role of Ink4a/Arf Locus in Beta Cell Mass Expansion under Physiological and Pathological Conditions

  title={Role of Ink4a/Arf Locus in Beta Cell Mass Expansion under Physiological and Pathological Conditions},
  author={E. Salas and N. Rabhi and P. Froguel and Jean-S{\'e}bastien Annicotte},
  journal={Journal of Diabetes Research},
  • E. Salas, N. Rabhi, +1 author Jean-Sébastien Annicotte
  • Published 2014
  • Biology, Medicine
  • Journal of Diabetes Research
  • The ARF/INK4A (Cdkn2a) locus includes the linked tumour suppressor genes p16INK4a and p14ARF (p19ARF in mice) that trigger the antiproliferative activities of both RB and p53. With beta cell self-replication being the primary source for new beta cell generation in adult animals, the network by which beta cell replication could be increased to enhance beta cell mass and function is one of the approaches in diabetes research. In this review, we show a general view of the regulation points at… CONTINUE READING
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