Role of Ink4a/Arf Locus in Beta Cell Mass Expansion under Physiological and Pathological Conditions

@article{Salas2014RoleOI,
  title={Role of Ink4a/Arf Locus in Beta Cell Mass Expansion under Physiological and Pathological Conditions},
  author={E. Salas and N. Rabhi and P. Froguel and Jean-S{\'e}bastien Annicotte},
  journal={Journal of Diabetes Research},
  year={2014},
  volume={2014}
}
  • E. Salas, N. Rabhi, +1 author Jean-Sébastien Annicotte
  • Published 2014
  • Biology, Medicine
  • Journal of Diabetes Research
  • The ARF/INK4A (Cdkn2a) locus includes the linked tumour suppressor genes p16INK4a and p14ARF (p19ARF in mice) that trigger the antiproliferative activities of both RB and p53. With beta cell self-replication being the primary source for new beta cell generation in adult animals, the network by which beta cell replication could be increased to enhance beta cell mass and function is one of the approaches in diabetes research. In this review, we show a general view of the regulation points at… CONTINUE READING
    10 Citations
    Islet biology, the CDKN2A/B locus and type 2 diabetes risk
    • 30
    • PDF
    Targeted epigenetic editing to increase adult pancreatic beta-cell proliferation
    • Highly Influenced
    • PDF
    Integration of ATAC-seq and RNA-seq identifies human alpha cell and beta cell signature genes
    • 121
    Cdkn2a deficiency promotes adipose tissue browning
    • 13
    • PDF
    Molecular Biomarkers of Health
    • PDF
    Omics-based biomarkers in the diagnosis of diabetes
    • 4
    • PDF

    References

    SHOWING 1-10 OF 73 REFERENCES
    Polycomb protein Ezh2 regulates pancreatic beta-cell Ink4a/Arf expression and regeneration in diabetes mellitus.
    • 322
    • PDF
    p16INK4a induces an age-dependent decline in islet regenerative potential
    • 883
    Epigenetic regulation of the INK4b-ARF-INK4a locus
    • 179
    The CDK4–pRB–E2F1 pathway controls insulin secretion
    • 99
    • PDF
    Role of the forkhead protein FoxO1 in beta cell compensation to insulin resistance.
    • 116
    • PDF
    The replication of beta cells in normal physiology, in disease and for therapy.
    • 150