Role of Infection in the Pathogenesis of Alzheimer’s Disease

@article{Holmes2009RoleOI,
  title={Role of Infection in the Pathogenesis of Alzheimer’s Disease},
  author={Clive Holmes and Darren Cotterell},
  journal={CNS Drugs},
  year={2009},
  volume={23},
  pages={993-1002}
}
While our understanding of the neuropathology of Alzheimer’s disease continues to grow, its pathogenesis remains a subject of intense debate. Genetic mutations contribute to a minority of early-onset autosomal dominant cases, but most cases are of either late-onset familial or sporadic form. CNS infections, most notably herpes simplex virus type 1, Chlamydophila pneumoniae and several types of spirochetes, have been previously suggested as possible aetiological agents in the development of… Expand
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References

SHOWING 1-10 OF 84 REFERENCES
Challenges and directions for the pathogen hypothesis of Alzheimer’s disease
This paper critically reviews the possibility that infiltration of the brain by pathogens (e.g. Herpes simplex virus type 1 (HSV1) or Chlamydophila pneumoniae (Cp)) acts as a trigger or co-factor forExpand
Herpes simplex virus type 1 in Alzheimer's disease: the enemy within.
TLDR
It is concluded that there is strong evidence that the virus, HSV1, is indeed a major factor in AD and therefore there is a strong case for appropriate treatment, and possibly for prevention in the future. Expand
Chlamydophila pneumoniae and the etiology of late-onset Alzheimer's disease.
TLDR
This review focuses specifically on infection with Chlamydophila (Chlamydia) pneumoniae in LOAD and how this infection may function as a "trigger or initiator" in the pathogenesis of this disease. Expand
Chronic inflammation and amyloidogenesis in Alzheimer's disease -- role of Spirochetes.
  • J. Miklossy
  • Medicine, Biology
  • Journal of Alzheimer's disease : JAD
  • 2008
TLDR
To consider the possibility that bacteria, including several types of spirochetes highly prevalent in the population at large or their persisting debris may initiate cascade of events leading to chronic inflammation and amyloid deposition in AD is important, as appropriate antibacterial and antiinflammatory therapy would be available to prevent dementia. Expand
Alzheimer's disease—a spirochetosis?
TLDR
Observations that in 14 autopsy cases with histopathologically confirmed AD, spirochetes were found in blood and cerebrospinal fluid and, moreover, could be isolated from brain tissue suggest that spiroChetes may be one of the causes of AD and that they may be the source of the β amyloid deposited in the AD brain. Expand
Failure To Detect Chlamydia pneumoniaein the Late-Onset Alzheimer's Brain
TLDR
It is concluded that C. pneumoniae is neither strongly nor uniquely associated with the neuropathology seen in late-onset Alzheimer's disease. Expand
Infection and Alzheimer's Disease: The APOE ε4 Connection and Lipid Metabolism
TLDR
A dangerous liaison between several viral and bacterial infections and the most significant genetic factor for AD, APOE epsilon4, is re-examine and the possible impact of this alliance on AD development is reviewed. Expand
Neuroinflammation: implications for the pathogenesis and molecular diagnosis of Alzheimer's disease.
TLDR
A solid set of discoveries has strengthened the idea that altered patterns in the glia-neuron interactions constitute early molecular events within the cascade of cellular signals that lead to neurodegeneration in AD. Expand
Systemic infection, interleukin 1β, and cognitive decline in Alzheimer’s disease
TLDR
This prospective pilot study in Alzheimer's disease subjects showed that cognitive function can be impaired for at least two months after the resolution of a systemic infection and that cognitive impairment is preceded by raised serum levels of interleukin 1β. Expand
Herpes simplex virus type 1, apolipoprotein E and Alzheimer' disease.
  • R. Itzhaki
  • Medicine
  • Herpes : the journal of the IHMF
  • 2004
TLDR
It is difficult to ascertain the role of an infectious agent in Alzheimer's disease due to the difficulty of establishing the timepoint at which the agent becomes involved, and further research into the possible link between herpesviruses and Alzheimer's Disease is required. Expand
...
1
2
3
4
5
...