Role of IgE in atopic dermatitis.

  title={Role of IgE in atopic dermatitis.},
  author={Donald Y. M. Leung},
  journal={Current opinion in immunology},
  volume={5 6},
Atopic dermatitis is a chronic inflammatory skin disease associated with elevated serum IgE levels and sensitization to a variety of inhalant, food and microbial allergens. Controlled challenges have provided substantial evidence that allergens can trigger acute IgE-mediated mast-cell dependent exacerbations of eczema in these patients. However, the sustained chronic skin inflammation that characterizes atopic dermatitis is likely to result from a local expansion of allergen-specific T helper… CONTINUE READING

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