Role of ITAM signaling module in signal integration.

  title={Role of ITAM signaling module in signal integration.},
  author={Jelena S. Bezbradica and Ruslan Medzhitov},
  journal={Current opinion in immunology},
  volume={24 1},
Diverse cell types use a small number of evolutionarily conserved signaling modules to integrate external cues and elicit distinct functions. A question thus arises as to how does a receptor, which contains a single signaling module, produce distinct outcomes to diverse signals, particularly if such module is shared amongst a family of receptors? Emerging data suggest that many immunoreceptors, all of which use a conserved ITAM-module for their signaling, can couple with members of additional… CONTINUE READING
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