Role of ITAM signaling module in signal integration.

@article{Bezbradica2012RoleOI,
  title={Role of ITAM signaling module in signal integration.},
  author={Jelena S. Bezbradica and Ruslan Medzhitov},
  journal={Current opinion in immunology},
  year={2012},
  volume={24 1},
  pages={58-66}
}
Diverse cell types use a small number of evolutionarily conserved signaling modules to integrate external cues and elicit distinct functions. A question thus arises as to how does a receptor, which contains a single signaling module, produce distinct outcomes to diverse signals, particularly if such module is shared amongst a family of receptors? Emerging data suggest that many immunoreceptors, all of which use a conserved ITAM-module for their signaling, can couple with members of additional… CONTINUE READING
Related Discussions
This paper has been referenced on Twitter 1 time. VIEW TWEETS

From This Paper

Figures, tables, and topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 21 extracted citations

A respiratory chain controlled signal transduction cascade in the mitochondrial intermembrane space mediates hydrogen peroxide signaling.

Proceedings of the National Academy of Sciences of the United States of America • 2015
View 2 Excerpts
Highly Influenced

Targeted Therapies in Adult B-Cell Malignancies

BioMed research international • 2015
View 4 Excerpts
Highly Influenced

References

Publications referenced by this paper.
Showing 1-10 of 59 references

Similar Papers

Loading similar papers…