Role of IL-17A in the development of colitis-associated cancer.

@article{Hyun2012RoleOI,
  title={Role of IL-17A in the development of colitis-associated cancer.},
  author={Yil Sik Hyun and Dong - Soo Han and Alison R. Lee and Chang Soo Eun and Jeehee Youn and Hang-Rae Kim},
  journal={Carcinogenesis},
  year={2012},
  volume={33 4},
  pages={931-6}
}
A close relationship between inflammation and colon cancer has been widely accepted, and interleukin (IL)-17A plays an important role in controlling colonic inflammation. However, the role of IL-17A has not yet been validated in colitis-associated cancer (CAC). This study aims to identify the effects of IL-17A in tumorigenesis utilizing IL-17A-deficient mice in an experimental CAC model. CAC was induced in both the IL-17A-deficient and the C57BL/6 (wild-type, WT) mice by injection of 12.5 mg/kg… CONTINUE READING
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SMAD 2 is essential for TGF beta - mediated Th 17 cell generation

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