Role of IL-10-producing regulatory B cells in control of cerebral malaria in Plasmodium berghei infected mice.

@article{Liu2013RoleOI,
  title={Role of IL-10-producing regulatory B cells in control of cerebral malaria in Plasmodium berghei infected mice.},
  author={Yunfeng Liu and Yue Chen and Zhaotao Li and Yingli Han and Yanxia Sun and Qiong Wang and Boyu Liu and Zhong Yuan Su},
  journal={European journal of immunology},
  year={2013},
  volume={43 11},
  pages={2907-18}
}
Cerebral malaria (CM) is a neurological syndrome often occurring in severe malaria. Although CM is known as an immunopathology in brain tissue mediated by excessive proinflammatory cytokines, the immunoregulatory mechanism is poorly understood. Here, we investigated the role of IL-10-producing regulatory B (Breg) cells in modulating CM development in a murine model of Plasmodium berghei ANKA infection. We observed that blood-stage P. berghei induced expansion of IL-10-producing Breg cells in… CONTINUE READING
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