Role of IL-10 deficiency in excessive nuclear factor-kappaB activation and lung inflammation in cystic fibrosis transmembrane conductance regulator knockout mice.

@article{Saadane2005RoleOI,
  title={Role of IL-10 deficiency in excessive nuclear factor-kappaB activation and lung inflammation in cystic fibrosis transmembrane conductance regulator knockout mice.},
  author={Aicha Saadane and Jindrich Soltys and Melvin Berger},
  journal={The Journal of allergy and clinical immunology},
  year={2005},
  volume={115 2},
  pages={405-11}
}
BACKGROUND Patients with cystic fibrosis (CF) and CF transmembrane conductance regulator knockout (CF-KO) mice are deficient in pulmonary IL-10 and have excessive inflammatory response to Pseudomonas aeruginosa infection. OBJECTIVE We hypothesized that local IL-10 deficiency in the lung was responsible for prolonged and excessive inflammatory responses and observations of inflammation in the absence of infection. METHODS To determine whether IL-10 deficiency could account for persistent… CONTINUE READING

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