Role of IL-1 receptor-associated kinase-M (IRAK-M) in priming of immune and inflammatory responses by nitrogen bisphosphonates.

Abstract

Nitrogen bisphosphonates (NBPs) are commonly prescribed for osteoporosis but have also been found to induce inflammatory reactions and to delay the progression of breast cancer. The inflammatory and anticancer effects of the NBPs might be associated with an ability to modulate innate immune signaling. In mice, intraperitoneal NBP administration causes a… (More)
DOI: 10.1073/pnas.1107899108

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Cite this paper

@article{Norton2011RoleOI, title={Role of IL-1 receptor-associated kinase-M (IRAK-M) in priming of immune and inflammatory responses by nitrogen bisphosphonates.}, author={John T. Norton and Tomoko Hayashi and Brian T Crain and Maripat Corr and Dennis Carson}, journal={Proceedings of the National Academy of Sciences of the United States of America}, year={2011}, volume={108 27}, pages={11163-8} }