Role of IGFBP-3 in the regulation of β-cell mass during obesity: adipose tissue/β-cell cross talk.


In obesity an increase in β-cell mass occurs to cope with the rise in insulin demand. This β-cell plasticity is essential to avoid the onset of hyperglycemia, although the molecular mechanisms that regulate this process remain unclear. This study analyzed the role of adipose tissue in the control of β-cell replication. Using a diet-induced model of obesity… (More)
DOI: 10.1210/en.2011-0181

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