Role of IGF-I signaling in regulating osteoclastogenesis.

@article{Wang2006RoleOI,
  title={Role of IGF-I signaling in regulating osteoclastogenesis.},
  author={Yongmei Wang and Shigeki Nishida and Hashem Z Elalieh and Roger K. Long and Bernard P. Halloran and Daniel D Bikle},
  journal={Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research},
  year={2006},
  volume={21 9},
  pages={
          1350-8
        }
}
UNLABELLED We showed that IGF-I deficiency impaired osteoclastogenesis directly and/or indirectly by altering the interaction between stromal/osteoblastic cells and osteoclast precursors, reducing RANKL and M-CSF production. These changes lead to impaired bone resorption, resulting in high BV/TV in IGF-I null mice. INTRODUCTION Although IGF-I has been clearly identified as an important growth factor in regulating osteoblast function, information regarding its role in osteoclastogenesis is… CONTINUE READING
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