Role of IGF-I in normal mammary development

@article{Kleinberg2004RoleOI,
  title={Role of IGF-I in normal mammary development},
  author={David L. Kleinberg},
  journal={Breast Cancer Research and Treatment},
  year={2004},
  volume={47},
  pages={201-208}
}
  • D. Kleinberg
  • Published 1 February 1998
  • Biology
  • Breast Cancer Research and Treatment
Growth hormone (GH) is now believed to be the pituitary factor that is responsible for mammary ductal morphogenesis. Mammary development at puberty occurs because of synergy between GH and estrogen on formation of terminal end buds (TEBs). TEBs extend into the substance of the mammary gland fat pad, resulting in ductal morphogenesis. Ultimately, the whole mammary fat pad accommodates a complex network of ducts. IGF-I or des(1-3) IGF-I mimic the actions of GH on TEB formation in… 

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Data on local expression of the IGFs, IGF receptors and IGFBPs is reviewed and the possible roles for these molecules in normal growth of mammary and breast tissue are discussed.

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Results demonstrate that a developmental IGF‐IR gene expression pattern exists in the mouse mammary gland and that increases in gene expression at specific phases of development may reflect an important role for IGF‐I/IGF‐IR at those phases ofDevelopment.

Obesity Alters Gene Expression for GH/IGF-I Axis in Mouse Mammary Fat Pads: Differential Role of Cortistatin and Somatostatin

The results offer new information on the factors (GH/IGF-I axis) involved in the endocrine/metabolic dysregulation of MFPs in obesity, and suggest that CORT is not a mere SST sibling in regulating MG physiology.

IGF and Insulin Action in the Mammary Gland: Lessons from Transgenic and Knockout Models

Results obtained from the application of transgenic and knockout mice to determine the roles of insulin and insulin-like growth factors (IGF)3 in the regulation of mammary gland development, lactation and tumorigenesis are focused on.
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