Role of IGF-I in normal mammary development

  title={Role of IGF-I in normal mammary development},
  author={D. Kleinberg},
  journal={Breast Cancer Research and Treatment},
  • D. Kleinberg
  • Published 2004
  • Medicine, Biology
  • Breast Cancer Research and Treatment
  • Growth hormone (GH) is now believed to be the pituitary factor that is responsible for mammary ductal morphogenesis. Mammary development at puberty occurs because of synergy between GH and estrogen on formation of terminal end buds (TEBs). TEBs extend into the substance of the mammary gland fat pad, resulting in ductal morphogenesis. Ultimately, the whole mammary fat pad accommodates a complex network of ducts. IGF-I or des(1-3) IGF-I mimic the actions of GH on TEB formation in… CONTINUE READING
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