Role of IFN regulatory factor 5 transcription factor in antiviral immunity and tumor suppression.

@article{Yanai2007RoleOI,
  title={Role of IFN regulatory factor 5 transcription factor in antiviral immunity and tumor suppression.},
  author={Hideyuki Yanai and Hui-min Chen and Takayuki Inuzuka and Seiji Kondo and Tak W Mak and Akinori Takaoka and Kenya Honda and T. Taniguchi},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2007},
  volume={104 9},
  pages={
          3402-7
        }
}
Host defense consists of two main aspects, namely, immune response to invading pathogens and suppression of tumor development. A family of transcription factors, IFN regulatory factors (IRFs), has recently gained much attention in terms of its critical role in linking these two aspects of host defense, wherein IRF5 was previously shown to play a critical role in the induction of proinflammatory cytokines by activation of Toll-like receptors. In the present study, using IRF5 gene-targeted mice… CONTINUE READING
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Proceedings of the National Academy of Sciences of the United States of America • 2008
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