Role of I1-Imidazoline Receptors and α2-Adrenoceptors in Hemodynamic Effects of Moxonidine Administration into the Rostroventrolateral Medulla

@article{Khokhlova2001RoleOI,
  title={Role of I1-Imidazoline Receptors and α2-Adrenoceptors in Hemodynamic Effects of Moxonidine Administration into the Rostroventrolateral Medulla},
  author={Oksana N Khokhlova and Arkady N. Murashev and Oleg S. Medvedev},
  journal={Bulletin of Experimental Biology and Medicine},
  year={2001},
  volume={131},
  pages={336-339}
}
Local injection of 4 nmol moxonidine (unilaterally) into the rostroventrolateral medulla of spontaneously hypertensive rats (SHR-SP) decreased mean blood pressure and heart rate by 24±3 and 3±4%, respectively. Pretreatment with the I1/α2-receptor antagonist efaroxan abolished the moxonidine-induced decrease in mean blood pressure, but had no effect on heart rate. Yohimbine blocked hypotension, delayed bradycardia (8 nmol), or completely inhibited the effects of moxonidine (16 nmol). Our results… CONTINUE READING