Role of Hypoxia Inducible Factor-1α (HIF-1α) in Innate Defense against Uropathogenic Escherichia coli Infection

@inproceedings{Lin2015RoleOH,
  title={Role of Hypoxia Inducible Factor-1α (HIF-1α) in Innate Defense against Uropathogenic Escherichia coli Infection},
  author={Ann En-Ju Lin and Federico C. Beasley and Joshua Olson and Nadia N Keller and Robert A. Shalwitz and Thomas J Hannan and Scott J Hultgren and Victor Nizet},
  booktitle={PLoS pathogens},
  year={2015}
}
Uropathogenic E. coli (UPEC) is the primary cause of urinary tract infections (UTI) affecting approximately 150 million people worldwide. Here, we revealed the importance of transcriptional regulator hypoxia-inducible factor-1 α subunit (HIF-1α) in innate defense against UPEC-mediated UTI. The effects of AKB-4924, a HIF-1α stabilizing agent, were studied… CONTINUE READING