Role of Hormonal and Other Factors in Human Prostate Cancer

@article{Wigle2008RoleOH,
  title={Role of Hormonal and Other Factors in Human Prostate Cancer},
  author={DonaldT. Wigle and Michelle C. Turner and J Gomes and Marie-{\'E}lise Parent},
  journal={Journal of Toxicology and Environmental Health, Part B},
  year={2008},
  volume={11},
  pages={242 - 259}
}
American men have a lifetime risk of about 18% for prostate cancer diagnosis. Large international variations in prostate cancer risks and increased risks among migrants from low- to high-risk countries indicate important roles for environmental factors. Major known risk factors include age, family history, and country/ethnicity. Type 2 diabetes appears to reduce risk, while high birth weight and adult height are linked to increased risk of aggressive prostate cancer. Limited evidence supports… Expand
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References

SHOWING 1-10 OF 251 REFERENCES
Circulating Steroid Hormones and the Risk of Prostate Cancer
TLDR
High levels of testosterone and adrenal androgens are associated with reduced risk of aggressive prostate cancer but not with nonaggressive disease, and negative but nonsignificant linear trends in risk for aggressive cancer were obtained. Expand
High levels of circulating testosterone are not associated with increased prostate cancer risk: A pooled prospective study
TLDR
No support was found for the hypothesis that high levels of circulating androgens within a physiologic range stimulate development and growth of prostate cancer. Expand
Hormonal predictors of prostate cancer: a meta-analysis.
TLDR
A meta-analysis of all previously published studies on hormonal predictors of risk for prostate cancer found that men with either serum testosterone or IGF-1 levels in upper quartile of the population distribution have an approximately two-fold higher risk for developing prostate cancer. Expand
Relationships of serum androgens and estrogens to prostate cancer risk: results from a prospective study in Finland.
  • J. Dorgan, D. Albanes, +7 authors P. Taylor
  • Medicine
  • Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
  • 1998
TLDR
These results do not support a strong relationship of serum androgens and estrogens with prostate cancer in smokers, and within-person variation in concentrations of some hormones may have contributed to the lack of significant associations. Expand
Prospective study of sex hormone levels and risk of prostate cancer.
TLDR
High levels of circulating testosterone and low levels of SHBG-both within normal endogenous ranges-are associated with increased risks of prostate cancer, and circulating levels of DHT and AAG do not appear to be strongly related to prostate cancer risk. Expand
The role of steroid hormones in prostate carcinogenesis.
  • M. Bosland
  • Medicine
  • Journal of the National Cancer Institute. Monographs
  • 2000
TLDR
A multifactorial general hypothesis of prostate carcinogenesis emerges with androgens as strong tumor promoters acting via androgen receptor-mediated mechanisms to enhance the carcinogenic activity of strong endogenous genotoxic carcinogens and possible weak environmental carcinogens of unknown nature. Expand
Cigarette smoking and risk of prostate cancer in middle-aged men.
  • L. A. Plaskon, D. Penson, T. Vaughan, J. Stanford
  • Medicine
  • Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
  • 2003
TLDR
Results from this study suggest that prostate cancer should be added to the list of tumors for which cigarette smoking is a risk factor and a dose-response relationship exists between number of pack-years smoked and cancer risk. Expand
Genetic Susceptibility to Prostate Cancer: Prostate-specific Antigen and its Interaction with the Androgen Receptor (United States)
TLDR
Evidence is found that the PSA*2*2 diplotype in combination with short AR CAG alleles increases a man’s risk of developing prostate cancer, which supports an etiologic role in prostate cancer of genetic interactions between polymorphisms that increase AR transactivation strength and those that alter the regulatory regions of target genes such as PSA that are responsive to androgen stimulation. Expand
Diabetes and risk of prostate cancer in a prospective cohort of US men.
TLDR
Investigation of the role of timing of diabetes diagnosis in relation to risk of prostate cancer among men in the Cancer Prevention Study II Nutrition Cohort showed that diabetes was associated with a lower incidence of prostatecancer. Expand
The role of obesity and related metabolic disturbances in cancers of the colon, prostate, and pancreas.
TLDR
Substantial evidence now supports a strong role for diabetes and obesity in pancreatic cancer etiology, and the mechanisms for these associations remain speculative and deserve further study. Expand
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