Role of Histone H3 Lysine 9 Methylation in Epigenetic Control of Heterochromatin Assembly

@article{Nakayama2001RoleOH,
  title={Role of Histone H3 Lysine 9 Methylation in Epigenetic Control of Heterochromatin Assembly},
  author={Jun-ichi Nakayama and Judd C Rice and Brian D. Strahl and C. David Allis and Shiv I. S. Grewal},
  journal={Science},
  year={2001},
  volume={292},
  pages={110 - 113}
}
The assembly of higher order chromatin structures has been linked to the covalent modifications of histone tails. We provide in vivo evidence that lysine 9 of histone H3 (H3 Lys9) is preferentially methylated by the Clr4 protein at heterochromatin-associated regions in fission yeast. Both the conserved chromo- and SET domains of Clr4 are required for H3 Lys9methylation in vivo. Localization of Swi6, a homolog ofDrosophila HP1, to heterochomatic regions is dependent on H3 Lys9 methylation… 
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