Role of Histone H3 Lysine 27 Methylation in Polycomb-Group Silencing

@article{Cao2002RoleOH,
  title={Role of Histone H3 Lysine 27 Methylation in Polycomb-Group Silencing},
  author={R. Cao and L. Wang and Hengbin Wang and L. Xia and H. Erdjument-Bromage and P. Tempst and R. S. Jones and Y. Zhang},
  journal={Science},
  year={2002},
  volume={298},
  pages={1039 - 1043}
}
  • R. Cao, L. Wang, +5 authors Y. Zhang
  • Published 2002
  • Biology, Medicine
  • Science
  • Polycomb group (PcG) proteins play important roles in maintaining the silent state of HOX genes. Recent studies have implicated histone methylation in long-term gene silencing. However, a connection between PcG-mediated gene silencing and histone methylation has not been established. Here we report the purification and characterization of an EED-EZH2 complex, the human counterpart of theDrosophila ESC-E(Z) complex. We demonstrate that the complex specifically methylates nucleosomal histone H3… CONTINUE READING
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