Role of Histone Deacetylases in Gene Regulation at Nuclear Lamina

@inproceedings{Milon2012RoleOH,
  title={Role of Histone Deacetylases in Gene Regulation at Nuclear Lamina},
  author={Beatrice C. Milon and Haibo Cheng and Mikhail V. Tselebrovsky and Sergei A. Lavrov and Valentina V. Nenasheva and Elena A. Mikhaleva and Yuri Y. Shevelyov and Dmitry I. Nurminsky},
  booktitle={PloS one},
  year={2012}
}
Theoretical models suggest that gene silencing at the nuclear periphery may involve "closing" of chromatin by transcriptional repressors, such as histone deacetylases (HDACs). Here we provide experimental evidence confirming these predictions. Histone acetylation, chromatin compactness, and gene repression in lamina-interacting multigenic chromatin domains… CONTINUE READING