Role of Heparin-Binding Growth-Associated Molecule (HB-GAM) in Hippocampal LTP and Spatial Learning Revealed by Studies on Overexpressing and Knockout Mice

@article{Pavlov2002RoleOH,
  title={Role of Heparin-Binding Growth-Associated Molecule (HB-GAM) in Hippocampal LTP and Spatial Learning Revealed by Studies on Overexpressing and Knockout Mice},
  author={Ivan Pavlov and Vootele V{\~o}ikar and Marko Kaksonen and Sari E. Lauri and Anni Hienola and Tomi Taira and Heikki Rauvala},
  journal={Molecular and Cellular Neuroscience},
  year={2002},
  volume={20},
  pages={330-342}
}
Heparin-binding growth-associated molecule (HB-GAM) is an extracellular matrix-associated protein with neurite outgrowth-promoting activity and which is suggested to be implicated in hippocampal synaptic plasticity. To study the functions of HB-GAM in adult brain we have produced HB-GAM overexpressing mice and compared phenotypic changes in the transgenic mice to those in the HB-GAM null mice. Both mutants were viable and displayed no gross morphological abnormalities. The basal synaptic… 
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References

SHOWING 1-10 OF 64 REFERENCES
Enhanced Hippocampal Long-Term Potentiation in Mice Lacking Heparin-Binding Growth-Associated Molecule
TLDR
It is suggested that HB-GAM acts as an inducible signal to inhibit LTP in hippocampus, which reverts back to the wild-type level by application of HB- GAM.
Effect of heparin‐binding growth‐associated molecule (HB‐GAM) on synaptic transmission and early LTP in rat hippocampal slices
TLDR
HB‐GAM did not depotentiate tetanus‐induced LTP or prevent heterosynaptic LTP induced by application of tetraethylammonium (TEA), indicating that the effect was limited to early, synapse‐specific stages of LTP induction.
Activity-induced enhancement of HB-GAM expression in rat hippocampal slices.
TLDR
The results indicate that high frequency stimulation inducing LTP results in calcium-dependent enhancement in HB-GAM expression, and imply a role for this extracellular protein in the modulation of synaptic function in the hippocampus.
Reg1ulatory Role and Molecular Interactions of a Cell-Surface Heparan Sulfate Proteoglycan (N-syndecan) in Hippocampal Long-Term Potentiation
TLDR
It is found that HSs play a crucial role in long-term potentiation (LTP), a finding that is consistent with the idea that converging molecular mechanisms are used in the development of neuron–target contacts and in activity-induced synaptic plasticity in adults.
Heparin-binding Growth-associated Molecule Contains Two Heparin-binding β-Sheet Domains That Are Homologous to the Thrombospondin Type I Repeat*
TLDR
It is suggested that the TSR sequence motif found in various extracellular proteins defines a β-sheet structure similar to that found in HB-GAM and midkine, and a similarity in biological functions is suggested by the occurrence of the T SR sequence motif in a wide variety of proteins that mediate cell-to-extracellular matrix and cell- to-cell interactions.
Reduced Perisomatic Inhibition, Increased Excitatory Transmission, and Impaired Long-Term Potentiation in Mice Deficient for the Extracellular Matrix Glycoprotein Tenascin-R
TLDR
It is shown that a deficit in TN-R results in reduction of perisomatic inhibition and, as a consequence, in an increase of excitatory synaptic transmission in CA1 to the levels close to saturation, impeding further expression of LTP.
Loss of Cadherin-11 Adhesion Receptor Enhances Plastic Changes in Hippocampal Synapses and Modifies Behavioral Responses
TLDR
The results suggest that the cad11-mediated junctions may modulate synaptic efficacy, confining its dynamic changes to a limited range, or these junctions are required for normal development of synaptic organization in the hippocampus.
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