Role of Helicobacter pylori plasticity region genes in development of gastroduodenal diseases.

@article{Sugimoto2012RoleOH,
  title={Role of Helicobacter pylori plasticity region genes in development of gastroduodenal diseases.},
  author={M Sugimoto and Masahide Watada and Sung Woo Jung and David Y Graham and Yoshio Yamaoka},
  journal={Journal of clinical microbiology},
  year={2012},
  volume={50 2},
  pages={441-8}
}
The plasticity region of Helicobacter pylori is a large chromosomal segment including isolate-specific open reading frames with characteristics of pathogenicity islands. It remains unclear whether genes in the plasticity region play a role in the pathogenesis of gastric mucosal inflammation and gastroduodenal disease. Our aim was to assess the role of selected genes in the plasticity region in relation to risk of H. pylori-related disease and the severity of gastric mucosal damage. We used PCR… CONTINUE READING