Role of Helicobacter pylori infection in the pathogenesis of minimal hepatic encephalopathy and effect of its eradication

@article{Agrawal2011RoleOH,
  title={Role of Helicobacter pylori infection in the pathogenesis of minimal hepatic encephalopathy and effect of its eradication},
  author={Avinash Agrawal and Alok Gupta and Mam Chandra and Sciddhartha Koowar},
  journal={Indian Journal of Gastroenterology},
  year={2011},
  volume={30},
  pages={29-32}
}
Background and AimHelicobacter pylori (H. pylori) bacteria convert urea to ammonia, which has been implicated in causation of hepatic encephalopathy in patients with liver cirrhosis. The role of H. pylori infection in causation of minimal hepatic encephalopathy (MHE) has not been well studied. We looked at the relationship of H. pylori infection with MHE and hyperammonemia in patients with liver cirrhosis and the effects of anti-H. pylori treatment in patients with MHE and H. pylori infection… 
EFFECT OF HELICOBACTER PYLORI ERADICATIONON THE PATHOGENESIS OF MINIMAL HEPATIC ENCEPHALOPATHY IN EGYPTIAN PATIENTS WITH LIVER CIRRHOSIS By MOHIE
TLDR
Number connection test and serum ammonia level were significantly improved in GI patients and positive H. pylori after eradication therapy, indicated that H.pylori infection is associated with high blood ammonia levels by urease enzyme and can lead to causation of HE.
Role of Helicobacter Pylori Infection in the Pathogenesis of Minimal Hepatic Encephalopathy and Effect of its Eradication
TLDR
H. pylori infection is common among cirrhotic Egyptian patients and its role in the pathogenesis of MHE and ammonia production was proved and Screening of cirrhosis patients for detection and eradication of H.pylori is beneficial in the improvement and cure of M HE for better quality of life.
Helicobacter pylori, hyperammonemia, and hepatic encephalopathy: the effect of its eradication on minimal hepatic encephalopathy
TLDR
Eradication of H. pylori infection ameliorates the manifestations of MHE and improves the results of both NCT and serum ammonia levels, however, further studies on the association between H.pylori infections and the pathogenesis of HE are strongly recommended.
Prevalence of Helicobacter pylori Infection in Patients with Minimal Hepatic Encephalopathy.
TLDR
The amount of ammonia produced by H. pylori does not affect venous ammonia levels, and an additional benefit of H.pylori eradication in the treatment of hepatic encephalopathy in patients with LC is unlikely to occur.
The role of Helicobacter pylori in minimal hepatic encephalopathy
TLDR
There is a highly significant association between H. pylori infection and MHE in cirrhotic patients and the treatment of H.pylori reduces the mean plasma ammonia levels and improves FCT results among the infected patients.
Minimal Hepatic Encephalopathy: Effect of H. pylori infection and small intestinal bacterial overgrowth treatment on clinical outcomes
TLDR
Treatment of SIBO significantly improved the state of MHE in cirrhosis, however eradication of Hp infection did not improve MHE significantly, and patients with low Model for End-Stage Liver Disease (MELD) score and belonging to Child class B had significantly better improvement in MHE.
Helicobacter Pylori and the Incidence of Hepatic Encephalopathy
TLDR
Cirrhotic patients (Child C) with positive H pylori were associated with higher incidence of HE, higher levels of ammonia and endotoxins than patients with negative H plyori.
Helicobacter pylori: Effect of coexisting diseases and update on treatment regimens.
TLDR
Two novel eradication regimens, namely concomitant and hybrid therapy, have proven more effective in patients with dual- (clarithromycin- and metronidazole-) resistant H. pylori strains in geographic regions with high clarithromyzin resistance.
Does H. pylori Eradication Therapy Benefit Patients With Hepatic Encephalopathy?: Systematic Review
TLDR
A systematic review of the role of H. pylori infection in the pathogenesis of (minimal) hepatic encephalopathy and the effect of eradication therapy on (M)HE found evidence from well-designed clinical studies is weak.
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