Role of HLA-A motifs in identification of potential CTL epitopes in human papillomavirus type 16 E6 and E7 proteins.

@article{Kast1994RoleOH,
  title={Role of HLA-A motifs in identification of potential CTL epitopes in human papillomavirus type 16 E6 and E7 proteins.},
  author={Wijbe Martin Kast and Remco M.P. Brandt and John Sidney and Jan Wouter Drijfhout and Ralph Teruo Kubo and Howard Grey and Cornelis J M Melief and Alessandro Sette},
  journal={Journal of immunology},
  year={1994},
  volume={152 8},
  pages={
          3904-12
        }
}
We have measured the binding affinity for five HLA-A alleles: HLA-A1 (A*0101), A2.1 (A*0201), A3 (A*0301), A11 (A*1101), and A24 (A*2401); of a set of all possible nonamer peptides (n = 240) of human papillomavirus type 16 E6 and E7 proteins. High affinity binding peptides were identified for each of the alleles, thus allowing us to select several candidates for CTL-based vaccines. Moreover, this unbiased set of peptides allowed an evaluation of the predictive value of HLA motifs derived either… CONTINUE READING

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