Role of HIV-1 subtype C envelope V3 to V5 regions in viral entry, coreceptor utilization and replication efficiency in primary T-lymphocytes and monocyte-derived macrophages

@article{Sundaravaradan2007RoleOH,
  title={Role of HIV-1 subtype C envelope V3 to V5 regions in viral entry, coreceptor utilization and replication efficiency in primary T-lymphocytes and monocyte-derived macrophages},
  author={Vasudha Sundaravaradan and Suman R Das and Rajesh Ramakrishnan and Shobha Sehgal and S. Gopalan and Nafees Ahmad and Shahid Jameel},
  journal={Virology Journal},
  year={2007},
  volume={4},
  pages={126 - 126}
}
Several subtypes of HIV-1 circulate in infected people worldwide, including subtype B in the United States and subtype C in Africa and India. To understand the biological properties of HIV-1 subtype C, including cellular tropism, virus entry, replication efficiency and cytopathic effects, we reciprocally inserted our previously characterized envelope V3–V5 regions derived from 9 subtype C infected patients from India into a subtype B molecular clone, pNL4-3. Equal amounts of the chimeric… CONTINUE READING