Role of HIF signaling on tumorigenesis in response to chronic low-dose arsenic administration.

@article{Kamat2005RoleOH,
  title={Role of HIF signaling on tumorigenesis in response to chronic low-dose arsenic administration.},
  author={Chandrashekhar D. Kamat and Dixy E. Green and Susan Curilla and Linda A. Warnke and Joshua W. Hamilton and Stefan Sturup and Callie Clark and Michael A. Ihnat},
  journal={Toxicological sciences : an official journal of the Society of Toxicology},
  year={2005},
  volume={86 2},
  pages={248-57}
}
Trivalent inorganic arsenic (arsenite, arsenic trioxide, As(III)) is a primary contaminant of groundwater supplies worldwide. As(III), marketed as trisenox, is also an FDA-approved agent to treat cancer It has been previously shown by our laboratory that As(III) administered at doses lower than a therapeutic anticancer dose results in an increase in tumor formation and blood vessel density of tumors. In this work it was found that chronic administration of As(III) approaching the EPA action… CONTINUE READING
29 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 29 extracted citations

Similar Papers

Loading similar papers…