Role of HIF-1 and NF-kappaB transcription factors in the modulation of transferrin receptor by inflammatory and anti-inflammatory signals.

@article{Tacchini2008RoleOH,
  title={Role of HIF-1 and NF-kappaB transcription factors in the modulation of transferrin receptor by inflammatory and anti-inflammatory signals.},
  author={Lorenza Tacchini and Elena Gammella and Cristina De Ponti and Stefania Recalcati and Gaetano Cairo},
  journal={The Journal of biological chemistry},
  year={2008},
  volume={283 30},
  pages={20674-86}
}
Inflammation generates various changes in body iron homeostasis, including iron sequestration in the reticuloendothelial system with ensuing hypoferremia and anemia of chronic disease. Increased iron accumulation is caused by hepcidin-mediated down-regulation of the iron export protein ferroportin and higher iron uptake. However, enhanced iron acquisition by macrophages cannot be accounted for by the previously reported transferrin receptor (TfR1) down-regulation in macrophages exposed to… CONTINUE READING

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