Role of HERP and a HERP-related protein in HRD1-dependent protein degradation at the endoplasmic reticulum.

@article{Huang2014RoleOH,
  title={Role of HERP and a HERP-related protein in HRD1-dependent protein degradation at the endoplasmic reticulum.},
  author={Chih-Hsiang Huang and Yue-Ru Chu and Yihong Ye and Xin Chen},
  journal={The Journal of biological chemistry},
  year={2014},
  volume={289 7},
  pages={4444-54}
}
Misfolded proteins of the endoplasmic reticulum (ER) are retrotranslocated to the cytosol and degraded by the proteasome via a process termed ER-associated degradation (ERAD). The precise mechanism of retrotranslocation is unclear. Here, we use several lumenal ERAD substrates targeted for degradation by the ubiquitin ligase HRD1 including SHH (sonic hedgehog) and NHK (null Hong Kong α1-antitrypsin) to study the geometry, organization, and regulation of the HRD1-containing ERAD machinery. We… CONTINUE READING
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